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KMID : 0371619870030020273
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Journal of Wonkwang Medical Science
1987 Volume.3 No. 2 p.273 ~ p.283
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Studies on Bradycardiac Effect of Oxymetazoline
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Abstract
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1. Oxymetazoline, which has been shown to act preferentially on a2-adrenoceptors in some peripheral tissues and to act on al adrenoceptors of the vascular smooth muscle and brain of the rabbit to induce a hypertensive effect, produced a bradycardiac effect in rabbits with the blockade of muscarinic receptors of the auricle by methylscopolamine pretreatment. It was attempted in this study to clarify the mechanism of this bradycardia.
2. The bradycardiac effect produced by either intravenous or intraventricular administration persisted until after the hypertension subsided.
3. The bradycardia of I .v. oxymetazoline was markedly inhibited by the treatment of rabbits with either guanethidine. Chlorisondamine or propranolol. It was hardly seen in reserpine-pretreated rabbits and cord-sectioned ones.
4. Both the hypertension and bradycardia of I . V. ´oxymetazoline were inhibited by I.v. prazosin.
5. Yohimbine (I.v.) did not affect the hypertension of I.v. oxymetazoline, but weakened the bradycardiac effect,´ although not significant.
6. The hypertensive effect of I. Vt. Oxymetazoline was reduced by I. Vt. Prazosin, but the bradycardia was not affected.
7. Yohimbine (I.vt.) did not affect the hypertension of I.vt. Oxymetazoline, but markedly reduced the bradycardiac effect.
8. The bradycardia of I .vt. Oxymetazoline was not seen in reserpine- pretreated rabbits and rabbits treated with both guanethidine and chlorisonda mine.
9. It is inferred that oxynietazoline induces the bradycardiac effect by acting on the a-adrenoceptors in the rabbit-heart and brain.
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